While this did little for growth, it resulted in crippling public debt.

That is a crippling cost disadvantage, as we've already seen at Grangemouth.

The devaluation of the currency dealt a crippling blow to the nation's economy.

The debt burden destroyed consumer confidence and undermined the banking system, crippling the economy.

Advocates of sanctions argue that they are having a crippling effect on the Iranian economy.

For nations that depend on trade, the sharp drop in exports this year was crippling.

Crippling sanctions, Secretary of State Hillary Clinton once said, though she quickly retracted that impromptu remark.

Al Qaeda, too, has an interest in crippling Karzai's government and is happy to exploit its Achilles heel.

That might seem crazy, especially given the likelihood of another round of economically crippling sanctions following the bombardment.

Al Qaeda, too, has an interest in crippling Karzai's government and is happy to exploit its Achilles heel.

But the truth is that China is a solitary, vulnerable rising power one that faces potentially crippling domestic challenges.

The political opposition has warned that if things don't change, Macedonia risks going the crippling economic way of Greece.

Yet, however crippling the effect of sanctions might be, they will not bring the regime to surrender its nuclear program.

Across sub Saharan Africa, many of the world's poorest people struggle with the crippling legacy of profligate lending to corrupt, oppressive rulers.

As long as crippling economic sanctions remain in place, the government will be unable to have its yellowcake and eat it, too.

Pensions have been reduced by 40 , on average, while the middle class is suffering under the weight of crippling new property taxes.

Among those who sought him out, his wife remembers, was an MI6 officer who had to live with the crippling after effects of torture.

If global temperatures exceed the two degree ceiling significantly, adaptation costs could reach double the worst case figures, placing a crippling burden on the world economy.

Bush s most promising initiative, promoting democracy across the Middle East, was already dealt a crippling blow by US intervention in Iraq and the ensuing civil war there.

Of course, but if you've seen the crippling poverty in some of these parts of the world it isn't a question of Let's leave the tree for tomorrow.

If it were understood, it could lead to cures for many crippling diseases, both neurological (like Parkinson s and Alzheimer s) and degenerative (including those, like cancer, associated with aging).

This is especially regrettable because R D in green energy technologies is really the only viable long term strategy for reducing fossil fuel consumption without crippling the world economy.

NEW YORK Continued discrimination against Roma in Europe not only violates human dignity, but is a major social problem crippling the development of Eastern European countries with large Roma populations.

This is especially regrettable because R amp D in green energy technologies is really the only viable long term strategy for reducing fossil fuel consumption without crippling the world economy.

NEW YORK Continued discrimination against Roma in Europe not only violates human dignity, but is a major social problem crippling the development of Eastern European countries with large Roma populations.

And the economic costs of restricted access to healthcare and education, on top of the scarcity of clear air and potable water, will be crippling in the mid and long term.

You are watching with legitimate concern (and a mixture of astonishment and anger) as Europe s crippling debt crisis spreads and America s dysfunctional politics leave it unable to revive its moribund economy.

Market reforms by themselves cannot lift a population from poverty if people are simultaneously struggling with epidemics of AIDS, or malaria, or tuberculosis, or chronic malnutrition, or other crippling health problems.

If Ukrainians do give these politicians bearing gifts their votes, they may continue to receive gifts at the next election, but meanwhile the rulers will keep ruining the country and crippling our souls.

The UN Security Council should provide an international framework in which the major powers pull back, lift crippling economic sanctions, and abide by political agreements reached by the region s own governments and factions. nbsp

But today, two years later, Iran must look again at where it is. As long as crippling economic sanctions remain in place, the government will be unable to have its yellowcake and eat it, too.

Though the deal does slow Iran s development of nuclear weapons, it does not restrain or even address the regime s hegemonic ambitions in the region, for which it has already spent billions of dollars and suffered crippling sanctions.

In early March less than three months after the acquisition Merck announced it would close down Cubist s early stage research unit, laying off some 120 staff and perhaps crippling its efforts to introduce new drugs into the pipeline.

Adding the Europe Region to the Americas, China and the Pacific Rim, means more than half the world's countries comprising over three billion people are now officially free of this crippling disease. The will to free the world of polio was underscored at the G8 summit in Canada, where G8 leaders pledged to help finish the job and rid Africa of the disease.